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 This page summarises the systematic analysis of all receptor kinases and phosphatases. We identify 4 classes of variants: 1) "Secreted Decoy" - secreted peptides lacking the transmembrane domain 2) "Tethered Decoy" - Type1 transmembrane receptors with a disrupted or removed catalytic domain 3) "Catalytic" - intracellular catalytic forms lacking ecto domain 4) "TMCatalytic" - intracellular membrane associated forms lacking the signal peptide, with domain structures similar to the Type2 transmembrane phosphoregulators Nok and Ptpn5. Decoy receptors - secreted Alk*2, Alk*1, Csf1r^, Egfr^28, Egfr^+28, Egfr^+28, Egfr^+28, Epha1+1, Epha10^*7, Epha10^*7, Epha3^+4, Epha3+4, Epha5*2, Epha52, Epha7*5, Ephb1+3, Flt1^+1, Flt1^+20, Flt33, Insr*3, Insrr+*2, Kdr+2, Met+2, Ptk7+2, Ptprc2, Ptprd+4, Ptprg*2, Ptprk^+*5, Ptprk^+5, Ptprn*1, Ptprn2+*8, Ptprn2+8, Ptprn2*2, Ptpro+*2, Ptprr*2, Ptprs*60, Ptprz1^+16 - tethered Axl+2, Bmpr1a2, Csf1r*3, Csf1r, Csf1r5, Epha4*2, Epha52, Epha5+2, Epha64, Epha7^+17, Epha7^+17, Epha7^+17, Ntrk2^+145, Ntrk2^7, Ntrk2^+145, Ntrk2^+2, Ntrk2^+145, Ntrk3^1, Pdgfra^+13, Pdgfra^+13, Ptprk+1, Ptprk+*1, Ptprm1, Ptpru2 - catalytic Acvr1c, Csf1r, Epha10, Fgfr1, Fgfr2, Kit^, Mertk, Ptpre^, Ptpre^, Ptprg, Ptprm, Ptpro^, Ptprs - Tmcat Axl, Ddr2, Epha6, Igf1r, Kit, Ntrk1, Ptprb, Ptprb, Ptpre^, Ptpro^, Ptpro^, Ptprr^, Ptprr^, Ptpru, Ror2, Tgfbr1 ^ isoform of this type previously reported For the secreted and tethered forms we also provide extra 3' quality information as there is the potential for adjunct A-rich regions in the introns of immature mRNAs to act as sites of mispriming by oligo-dT. Sequences missing a polyA signal and containing an adjunctA rich region may be artefactual. + polyA signal detected * adjunct A rich region detected in genome 3' of this cDNA count - number of supporting 3' events for this 3' end |